Xiaoxian(Sally) An, PhD

Experience

• 

  West China Hospital

  Jul 2013 - Jul 2013

  Pharmacy Intern

  Rotation in Pharmacy Department, clinical wards, dispensary

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  University of Cincinnati

  Aug 2014 - Feb 2020

  Graduate Assistant

  • Tested therapeutic modalities to improve targeted drug delivery including animal studies.• Performed data analysis utilizing SigmaPlot and prepared scientific reports for internal and external use.• Collaborated in project teams with mechanical engineers, surgeons, pharmacologists, preclinical safety and translational medicine scientists to advance novel agents into clinical development.• Acted as in vitro and in vivo pharmacology interface with early discovery project teams, communicated data and presentations.• Designed and conducted in-vivo studies including behavioral mouse studies and in-vivo cell- based assays.• Managed research related documentation including study plans, data files and scientific reports supporting regulatory filings.• Led the development of strategies and execute studies in the field of peripheral neuropathies• Assessed the biodegradability and tissue immune response to the biomaterial using in vitro and in vivo models.• Communicated research results to internal and external stakeholders including collaborators, leaders and partners across functions and academic institutions. Show less

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  University of Maryland, Baltimore (UMB)

  Mar 2020 - Mar 2022

  Postdoctoral Fellow

  •Led a discovery project to develop novel small molecules for psychiatric and neurological conditions•Delivered scientific reports and managed relationships with research partners and academic institutions• Designed and conducted in-vivo studies including behavioral mouse studies and perform AAV gene experiment • Utilized neurophysiological techniques to assess behavioral endpoints and neurocircuit modulation (stereotaxic surgery and optogenetics)• Conducted experiments and developed assays critical to understand in-vivo therapeutic activity, efficacy, and side effects • Applied behavioral and neurophysiological techniques to drug development utilizing statistical software (GraphPad) Show less

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  Weill Cornell Medicine

  Mar 2022 - now

  • Validating resistant and susceptible genes discovered through next generation sequencing in activated B-cell diffuse large B cell lymphoma (ABC-DLBCL) cell lines using sgRNA and shRNA knockout system in flow cytometers.• Elucidating molecular signaling pathways which MALT1 inhibitors sensitization and enriched hits are involved in. • Generating immunocompetent genetically engineered mouse lymphoma models • Testing response to different types of MALT1 inhibitors in patient derived xenograft (PDX) samples using growth inhibition in 2D and 3D cultures. • Breeding BCL10R58Q and BCL10E140X mice and perform genotyping and immunophenotyping. Show less

  • Research Associate

    Apr 2024 - now

  • Research Asscociate

    Mar 2022 - Apr 2024